CYP2D6 polymorphism in Parkinson's disease : The Rotterdam study
Identifieur interne : 004900 ( Main/Exploration ); précédent : 004899; suivant : 004901CYP2D6 polymorphism in Parkinson's disease : The Rotterdam study
Auteurs : B. Sanjay Harhangi [Pays-Bas] ; Ben A. Oostra [Pays-Bas] ; Peter Heutink [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Monique M. B. Breteler [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2001.
Descripteurs français
- Pascal (Inist)
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- topic : Adulte.
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Abstract
The CYP2D6 polymorphism has been studied extensively in association with Parkinson's disease (PD), with no consistent results. Several explanations, such as differences in study design or bias in the selection of the control population, have been offered for these inconsistent results. We designed a case control study nested within a prospective population-based cohort study in which cases and controls were sampled from the same source population. To assess the significance of the CYP2D6 gene in PD, we investigated two mutant alleles. CYP2D6*3 and CYP2D6*4, associated with poor metabolism and the wild type allele in 80 patients with PD and 156 matched controls, frequency matched on age and gender. No differences between cases and controls were found for the poor metabolizer genotype. However, we found that in contrast to earlier reports, the CYP2D6*4 mutant allele frequency was lower in cases as compared to controls, albeit not statistically significant. Our result supports the hypothesis that the CYP2D6 gene is not a major gene responsible for PD.
Affiliations:
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Sanjay Harhangi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. 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Van Duijn</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Allele</term><term>Frequency</term><term>Genetic determinism</term><term>Mutation</term><term>Parkinson disease</term><term>Polymorphism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Polymorphisme</term><term>Mutation</term><term>Allèle</term><term>Fréquence</term><term>Déterminisme génétique</term><term>Adulte</term><term>Gène CYP2D6</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The CYP2D6 polymorphism has been studied extensively in association with Parkinson's disease (PD), with no consistent results. Several explanations, such as differences in study design or bias in the selection of the control population, have been offered for these inconsistent results. We designed a case control study nested within a prospective population-based cohort study in which cases and controls were sampled from the same source population. To assess the significance of the CYP2D6 gene in PD, we investigated two mutant alleles. CYP2D6<sup>*</sup>3 and CYP2D6<sup>*</sup>4, associated with poor metabolism and the wild type allele in 80 patients with PD and 156 matched controls, frequency matched on age and gender. No differences between cases and controls were found for the poor metabolizer genotype. However, we found that in contrast to earlier reports, the CYP2D6<sup>*</sup>4 mutant allele frequency was lower in cases as compared to controls, albeit not statistically significant. Our result supports the hypothesis that the CYP2D6 gene is not a major gene responsible for PD.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Sanjay Harhangi, B" sort="Sanjay Harhangi, B" uniqKey="Sanjay Harhangi B" first="B." last="Sanjay Harhangi">B. Sanjay Harhangi</name></noRegion><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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